Cryptic phosphorylation in nucleoside natural product biosynthesis

November 30th, 2020 by Matthew M. Draelos

Nature Chemical Biology, Published online: 30 November 2020; doi:10.1038/s41589-020-00656-8

Rather than their expected role in self-immunity, kinases encoded in the biosynthetic gene clusters of nucleoside natural products catalyze the phosphorylation of an early intermediate, a modification that is later removed in a downstream step.