Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

October 16th, 2018 by Martina Wallace

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues

Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues, Published online: 16 October 2018; doi:10.1038/s41589-018-0132-2

mmBCFAs are endogenous fatty acids synthesized from BCAAs by brown and white adipose tissue via CrAT and FASN promiscuity. BCAA catabolism and mmBCFA lipogenesis are decreased by obesity-induced adipose hypoxia and influenced by the microbiome.
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