E2 enzymes: lessons in ubiquitin transfer from XLID patients

December 10th, 2018 by Martina Foglizzo

E2 enzymes: lessons in ubiquitin transfer from XLID patients

E2 enzymes: lessons in ubiquitin transfer from XLID patients, Published online: 10 December 2018; doi:10.1038/s41589-018-0191-4

Characterization of a novel mutation in the E2 ubiquitin-conjugating enzyme UBE2A accounts for the decreased activity of the mutant enzyme that underlies disease and provides important insight into the catalytic mechanism of E2s.