Channeling a complex question

August 18th, 2020 by Martin St. Maurice

Nature Chemical Biology, Published online: 18 August 2020; doi:10.1038/s41589-020-0619-5

It is generally believed that large protein complexes provide a catalytic advantage due to substrate channeling between enzymatic domains. However, the structure and function of the pentafunctional AROM complex suggests a noteworthy exception.