A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis

October 7th, 2019 by Mark F. van Delft

Nature Chemical Biology, Published online: 07 October 2019; doi:10.1038/s41589-019-0365-8

A phenotypic screen led to the identification of potent inhibitors of mouse BAK-driven apoptosis. The compounds interact with VDAC2 and stabilize its interaction with BAK, blocking apoptosis at an early stage to preserve long-term cell survival.
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