STACKing the odds for discoveries

March 8th, 2021 by Mariluz Soula

Nature Chemical Biology, Published online: 08 March 2021; doi:10.1038/s41589-021-00743-4

Characterization of cell death kinetics identifies new on- and off-target small-molecule modulators of ferroptosis and reveals a role of amino acid metabolism in regulating ferroptosis sensitivity.

Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers

August 10th, 2020 by Mariluz Soula

Nature Chemical Biology, Published online: 10 August 2020; doi:10.1038/s41589-020-0613-y

Genetic screens reveal a compendium of metabolic modifiers of lipid peroxidation. Tetrahydrobiopterin is essential under GPX4 inhibition, acting as a radical-trapping antioxidant that inhibits lipid peroxidation and is regenerated by DHFR.
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