Drug selectivity: Running in the family
July 6th, 2014 by Marcel Muelbaier
Nature Chemical Biology 10, 608 (2014). doi:10.1038/nchembio.1585
Authors: Marcel Muelbaier & Gerard Drewes
Comprehensive selectivity profiling is key for the development of safe drugs. Few current methods are capable of profiling large compound sets against entire target classes. The new EnPlex method expands the existing toolbox, allowing for the surveying of the serine hydrolase enzyme family.