GPCRs: Heterodimer-specific signaling

March 18th, 2015 by Marc Parmentier

Nature Chemical Biology 11, 244 (2015). doi:10.1038/nchembio.1772

Author: Marc Parmentier

Heterodimerization of G protein–coupled receptors can lead to the activation of intracellular pathways that are not triggered by either of the individual receptors. This property may lead to the development of new therapeutic approaches showcasing increased efficiency and selectivity.