DNA repair complex licenses acetylation of H2A.Z.1 by KAT2A during transcription

September 16th, 2019 by M. Semer

Nature Chemical Biology, Published online: 16 September 2019; doi:10.1038/s41589-019-0354-y

KAT2A acetylates histone variant H2A.Z to regulate transactivation of XPC and RAR positively regulated genes. The DNA repair complex XPC–RAD23–CEN2 interacts with H2A.Z and KAT2A to license the latter’s histone acetyltransferase activity.
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