Dynamic Regulation of NMDA and AMPA Receptors by Posttranslational Modifications [Neurobiology]

October 9th, 2015 by Lussier, M. P., Sanz-Clemente, A., Roche, K. W.

Many molecular mechanisms underlie the changes in synaptic glutamate receptor content that are required by neuronal networks to generate cellular correlates of learning and memory. During the last decade, posttranslational modifications have emerged as critical regulators of synaptic transmission and plasticity. Notably, phosphorylation, ubiquitination and palmitoylation control the stability, trafficking and synaptic expression of glutamate receptors in the central nervous system. In the current review, we will summarize some of the progress made by the neuroscience community regarding our understanding of phosphorylation, ubiquitination and palmitoylation of the NMDA and AMPA subtypes of glutamate receptors.