Allosteric interactions in the parathyroid hormone GPCR–arrestin complex formation

July 6th, 2020 by Lisa J. Clark

Nature Chemical Biology, Published online: 06 July 2020; doi:10.1038/s41589-020-0567-0

Characterization of the interaction between PTH and its G-protein-coupled receptor, PTHR, shows conformational changes coupled to residues interacting with His9, which helps position the PTH N terminus at the PTHR transmembrane domain to facilitate β-arrestin coupling.
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