Substrate-assisted enzymatic formation of lysinoalanine in duramycin

September 3rd, 2018 by Linna An

Substrate-assisted enzymatic formation of lysinoalanine in duramycin

Substrate-assisted enzymatic formation of lysinoalanine in duramycin, Published online: 03 September 2018; doi:10.1038/s41589-018-0122-4

During the biosynthesis of the lanthipeptide duramycin, DurN catalyzes stereospecific lysinoalanine formation by preorganizing the reactive conformation of the substrate, such that one of the substrate’s own residues serves as the catalytic base.