Host-Pathogen interactions: Nucleotide circles of life and death

January 19th, 2017 by Lingyin Li

Nature Chemical Biology 13, 130 (2017). doi:10.1038/nchembio.2289

Author: Lingyin Li

A phosphodiesterase, CdnP, from Mycobacterium tuberculosis (M. tb.) helps the pathogen evade immune detection by degrading the second messenger cyclic di-AMP that alerts the host to its presence. Genetic knockout of CdnP dampens the virulence of the pathogen, suggesting that CdnP inhibitors are potential anti–M. tb. therapeutics.

Erratum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

August 18th, 2015 by Lingyin Li

Nature Chemical Biology 11, 741 (2015). doi:10.1038/nchembio0915-741c

Author: Lingyin Li, Qian Yin, Pia Kuss, Zoltan Maliga, José L Millán, Hao Wu & Timothy J Mitchison

  • Posted in Nat Chem Biol, Publications
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Corrigendum: Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

February 17th, 2015 by Lingyin Li

Nature Chemical Biology 11, 235 (2015). doi:10.1038/nchembio0315-235d

Author: Lingyin Li, Qian Yin, Pia Kuss, Zoltan Maliga, José L Millán, Hao Wu & Timothy J Mitchison

  • Posted in Nat Chem Biol, Publications
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Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs

October 26th, 2014 by Lingyin Li

Nature Chemical Biology 10, 1043 (2014). doi:10.1038/nchembio.1661

Authors: Lingyin Li, Qian Yin, Pia Kuss, Zoltan Maliga, José L Millán, Hao Wu & Timothy J Mitchison

  • Posted in Nat Chem Biol, Publications
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