Unfolded Protein Response Signaling and Metabolic Diseases [Signal Transduction]

December 9th, 2013 by Lee, J., Ozcan, U.

The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding and traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to activation of complex signaling cascade called unfolded protein response (UPR). Recent studies have documented that UPR coordinates multiple signaling pathways and controls various physiologies in cells and the whole organism. Furthermore, unresolved ER stress has been implicated in a variety of metabolic disorders such as obesity and type 2 diabetes. Therefore, intervening ER stress and modulating signaling components of the UPR would provide promising therapeutics for the treatment of human metabolic diseases.