Labeling: Palladium brings proteins to life

April 17th, 2014 by Kun Qian

Nature Chemical Biology 10, 328 (2014). doi:10.1038/nchembio.1507

Authors: Kun Qian & Yujun George Zheng

A bioorthogonal decaging strategy, mediated by small-molecule palladium compounds, can recover the lysine-dependent activity of cellular proteins. This activation technique could be generally applicable for controlling and probing function of a protein target in living cells.