Computational design of G Protein-Coupled Receptor allosteric signal transductions

December 2nd, 2019 by Kuang-Yui Michael Chen

Nature Chemical Biology, Published online: 02 December 2019; doi:10.1038/s41589-019-0407-2

A computational approach for designing GPCRs with new signaling functions including allosteric signaling properties yielded D2 receptor variants with predictable G-protein signaling responses, some with enhanced potency and responses to dopamine.
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