Protein Ser/Thr/Tyr Phosphorylation in the Archaea [Genomics and Proteomics]

February 19th, 2014 by Kennelly, P. J.

ABSTRACT The third domain of life, the Archaea (formerly Archaebacteria), is populated by a physiologically diverse set of microorganisms, many of which reside at the ecological extremes of our global environment. Though ostensibly prokaryotic in morphology, the Archaea share much closer evolutionary ties to the Eucarya than to the superficially more similar Bacteria. Initial genomic, proteomic, and biochemical analyses have revealed the presence of eukaryotic protein kinases and phosphatases, and an intriguing set of serine, threonine and tyrosine phosphorylated proteins, in the Archaea that may offer new insights into this important regulatory mechanism.