A small-molecule inhibitor of C5 complement protein
June 17th, 2019 by Keith Jendza
Nature Chemical Biology, Published online: 17 June 2019; doi:10.1038/s41589-019-0303-9
An inhibitor of the complement pathway of the innate immune system targets the human complement component 5 protein (C5) by binding to an interfacial pocket to prevent its proteolytic cleavage by the last enzyme of the complement pathway, C5 convertase.