Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C<sup>Cdc20</sup>
March 9th, 2020 by Katherine V. Richeson
Nature Chemical Biology, Published online: 09 March 2020; doi:10.1038/s41589-020-0495-z
A small-molecule ligand of the APC/C activator Cdc20, which prolongs mitosis in unperturbed cells, instead shortens mitosis when the spindle checkpoint is activated, producing an opposite effect in a different regulatory context.