Paradoxical mitotic exit induced by a small molecule inhibitor of APC/C<sup>Cdc20</sup>

March 9th, 2020 by Katherine V. Richeson

Nature Chemical Biology, Published online: 09 March 2020; doi:10.1038/s41589-020-0495-z

A small-molecule ligand of the APC/C activator Cdc20, which prolongs mitosis in unperturbed cells, instead shortens mitosis when the spindle checkpoint is activated, producing an opposite effect in a different regulatory context.
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