Ferroptosis: Oxidized PEs trigger death

November 14th, 2016 by Katharina D'Herde

Nature Chemical Biology 13, 4 (2017). doi:10.1038/nchembio.2261

Authors: Katharina D'Herde & Dmitri V Krysko

Ferroptosis is characterized by accumulation of lipid peroxidation products and lethal ROS, but the source and identity of lipid death signals that cause toxicity are poorly defined. New studies reveal that ACSL4 controls sensitivity to ferroptosis and that oxidized phosphatidylethanolamines are critical for ferroptosis execution.