Structures shed light on prostanoid signaling

December 3rd, 2018 by Kaspar Hollenstein

Structures shed light on prostanoid signaling

Structures shed light on prostanoid signaling, Published online: 03 December 2018; doi:10.1038/s41589-018-0178-1

Prostanoids signal through G-protein-coupled receptors to regulate diverse physiological processes. Structures of three prostanoid receptors in inactive and active conformations now uncover the molecular determinants of ligand recognition and receptor activation and offer new opportunities for drug discovery.