Antibiotics: Synergistic MRSA combinations

October 20th, 2015 by Karen Bush

Nature Chemical Biology 11, 832 (2015). doi:10.1038/nchembio.1935

Author: Karen Bush

Meropenem/piperacillin/tazobactam is a triple β-lactam combination that kills MRSA in vitro and in a mouse model through a novel synergistic mechanism of action. Similar activity for other carbapenem/β-lactam combinations suggests that MRSA infections might be treatable with combinations of established β-lactams currently classified as ineffective against MRSA.