Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function

December 10th, 2018 by Ka-Hei Siu

Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function

Riboregulated toehold-gated gRNA for programmable CRISPR–Cas9 function, Published online: 10 December 2018; doi:10.1038/s41589-018-0186-1

Engineering of toehold-gated guide RNA (thgRNA) by tethering toehold riboswitches to sgRNAs enables the activation of CRISPR–Cas9 genome editing or transcriptional regulation in response to complementary synthetic or endogenous cellular RNAs.
  • Posted in Nat Chem Biol, Publications
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