Scaffold and organism hopping with chemical probes

April 16th, 2019 by Jürg Gertsch

Scaffold and organism hopping with chemical probes

Scaffold and organism hopping with chemical probes, Published online: 16 April 2019; doi:10.1038/s41589-019-0275-9

Chemical probes that irreversibly inhibit protein function may be used across species to discover proteins. Combining phenotypic screening and activity-based protein profiling, a new study uncovers a discrete lipid signaling pathway regulating lifespan in the worm Caenorhabditis elegans.