Dynamics of the context-specific translation arrest by chloramphenicol and linezolid

December 16th, 2019 by Junhong Choi

Nature Chemical Biology, Published online: 16 December 2019; doi:10.1038/s41589-019-0423-2

Single-molecule FRET technologies reveal the mechanism of sequence-specific translational inhibition induced by two antibiotics, chloramphenicol and linezolid, where aminoacyl-tRNA was repeatedly rejected from the A-site and failed to form a peptide bond.
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