Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-β

March 6th, 2015 by Jun Kuai, Lidia Mosyak, Jon Brooks, Michael Cain, Gregory J. Carven, Shinji Ogawa, Tetsuya Ishino, May Tam, Edward R. Lavallie, Zhiyong Yang, Dirk Ponsel, Robert Rauchenberger, Robert Arch and Nick Pullen

TOC Graphic

Biochemistry
DOI: 10.1021/bi5015425