Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

May 13th, 2019 by Juan Pablo Maianti

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

Nature Chemical Biology, Published online: 13 May 2019; doi:10.1038/s41589-019-0271-0

High-throughput screening identifies compounds that target insulin-degrading enzyme (IDE) and X-ray co-crystallography reveals how these compounds block insulin degradation by IDE but support its proteolysis of other substrates, including glucagon.
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