Small-molecule inhibitors: bULKing up mTOR inhibition

September 17th, 2015 by Jonathan M Goodwin

Nature Chemical Biology 11, 758 (2015). doi:10.1038/nchembio.1909

Authors: Jonathan M Goodwin & Leon O Murphy

A new small-molecule inhibitor of the autophagy-initiating kinase ULK1 serves to block a critical survival mechanism activated upon inhibition of mTORC1, potentially enhancing treatment efficacy for mTOR inhibitors currently in clinical trials for cancer treatment.