A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

May 11th, 2020 by Jonathan M. Ghergurovich

Nature Chemical Biology, Published online: 11 May 2020; doi:10.1038/s41589-020-0533-x

Identification of an improved glucose-6-phosphate dehydrogenase (G6PD) inhibitor G6PDi-1 blocks G6PD activity more robustly than the widely cited antagonist DHEA. G6PDi-1 treatment blocks T cell cytokine production and neutrophil oxidative burst.
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