Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles

March 30th, 2020 by John K. Eaton

Nature Chemical Biology, Published online: 30 March 2020; doi:10.1038/s41589-020-0501-5

Nitrile-oxide electrophiles were identified as covalent inhibitors of GPX4 that exhibit increased selectivity and reduced off-target effects relative to chloroacetamide-based inhibitors.
  • Posted in Nat Chem Biol, Publications
  • Comments Off on Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles