Optical control of sphingosine-1-phosphate formation and function

April 29th, 2019 by Johannes Morstein

Optical control of sphingosine-1-phosphate formation and function

Optical control of sphingosine-1-phosphate formation and function, Published online: 29 April 2019; doi:10.1038/s41589-019-0269-7

A photoswitchable analog of spingosine-1-phosphate (S1P) that allows for modulation of the action of this bioactive lipid exhibits prolonged metabolic stability compared to S1P, activates S1P receptors in cells and mediates nociception in mice.