Activation and reduction of carbon dioxide by nitrogenase iron proteins

November 28th, 2016 by Johannes G Rebelein

Nature Chemical Biology 13, 147 (2017). doi:10.1038/nchembio.2245

Authors: Johannes G Rebelein, Martin T Stiebritz, Chi Chung Lee & Yilin Hu

The iron (Fe) proteins of molybdenum (Mo) and vanadium (V) nitrogenases mimic carbon monoxide (CO) dehydrogenase in catalyzing the interconversion between CO2 and CO under ambient conditions. Catalytic reduction of CO2 to CO is achieved in vitro and in vivo upon redox changes of the Fe-protein-associated [Fe4S4] clusters. These observations establish the Fe protein as a model for investigation of CO2 activation while suggesting its biotechnological adaptability for recycling the greenhouse gas into useful products.

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