Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair
December 31st, 2018 by Jingli Hou
Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair
Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair, Published online: 31 December 2018; doi:10.1038/s41589-018-0190-5
A NO delivery system that depends on the hydrolysis of an alkyl-galactose-conjugated NO prodrug by an engineered galactosidase developed using a ‘bump-and-hole’ strategy enabled targeted delivery of NO to specific tissues.