Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

December 31st, 2018 by Jingli Hou

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair

Targeted delivery of nitric oxide via a ‘bump-and-hole’-based enzyme–prodrug pair, Published online: 31 December 2018; doi:10.1038/s41589-018-0190-5

A NO delivery system that depends on the hydrolysis of an alkyl-galactose-conjugated NO prodrug by an engineered galactosidase developed using a ‘bump-and-hole’ strategy enabled targeted delivery of NO to specific tissues.
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