An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

September 28th, 2020 by Jin-Fan Zhang

Nature Chemical Biology, Published online: 28 September 2020; doi:10.1038/s41589-020-00660-y

A fluorescence-based sensor of PKA activity has increased brightness, dynamic range and signal-to-noise ratio over related sensors and is useful for visualizing kinase activity in HeLa cells, primary neurons and the cortex of awake mice.
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