Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation

May 17th, 2019 by Jie Tu

Nature Chemical Biology, Published online: 17 May 2019; doi:10.1038/s41589-019-0290-x

Structural analysis of uracil DNA glycosylase reveals that its high affinity with DNA substrates derives from a stable intermediate that is formed by conservative H109 in a protruding loop covalently binding to the abasic site after uracil is excised.
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