Site-specific m<sup>6</sup>A editing

August 5th, 2019 by Jiangbo Wei

Nature Chemical Biology, Published online: 05 August 2019; doi:10.1038/s41589-019-0349-8

The N6-methyladenosine modification on RNA affects almost all steps of RNA metabolism. A new approach, using the CRISPR-based technology to modulate m6A level in mRNA, enables direct functional interrogation of site-specific m6A.