Deciphering the BRCA1 Tumor Suppressor Network [Cell Biology]

June 5th, 2015 by Jiang, Q., Greenberg, R.

The BRCA1 tumor suppressor protein is a central constituent of several distinct macromolecular protein complexes that execute homology directed DNA damage repair and cell cycle checkpoints. Recent years have borne witness to an exciting phase of discovery at the basic molecular level for how this network of DNA repair proteins acts to maintain genomic stability and suppress cancer. The clinical dividends of this investment are now being realized with the approval of first in class, BRCA targeted therapies for ovarian cancer and identification of molecular events that determine responsiveness to these agents. Further delineation of the basic science underlying BRCA network function holds promise to maximally exploit genome instability for therapy of hereditary and sporadic cancers.