Tightening a deadly pore former

February 18th, 2019 by Jialing Lin

Tightening a deadly pore former

Tightening a deadly pore former, Published online: 18 February 2019; doi:10.1038/s41589-019-0235-4

A small molecule was identified that binds to a unique site on the pro-apoptotic protein BAX, stabilizing the protein structure allosterically and preventing the conformational activation to a pore former by BH3 proteins.