Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

June 17th, 2019 by Jessica N. Spradlin

Nature Chemical Biology, Published online: 17 June 2019; doi:10.1038/s41589-019-0304-8

The natural product nimbolide covalently reacts with a functional cysteine of the E3 ubiquitin ligase RNF114, resulting in impaired substrate recognition and degradation, enabling the use of nimbolide for targeted protein degradation.
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