Deform the membrane, cAPTure the lipid

March 11th, 2021 by Jennifer Greaves

Nature Chemical Biology, Published online: 11 March 2021; doi:10.1038/s41589-021-00754-1

Acyl protein thioesterases are critical regulators of S-acylation, removing acyl chains from dynamically S-acylated proteins. A cytosolic deacylase, APT2, is S-acylated by zDHHC3 and zDHHC7 and is predicted to deform the lipid bilayer to extract acyl chains, capturing them within a hydrophobic pocket.