Methods: A small-molecule SMASh hit

August 18th, 2015 by Jeffrey Hannah

Nature Chemical Biology 11, 637 (2015). doi:10.1038/nchembio.1886

Authors: Jeffrey Hannah & Pengbo Zhou

There are many techniques that can be employed to control gene expression at the post-translational level. However, a novel system called SMASh (small molecule–assisted shutoff), which allows for chemically-induced degradation of target proteins, presents some distinct advantages.