<i>Mycobacterium tuberculosis</i> releases an antacid that remodels phagosomes

August 19th, 2019 by Jeffrey Buter

Nature Chemical Biology, Published online: 19 August 2019; doi:10.1038/s41589-019-0336-0

Buter et al. elucidated the biological function of the terpene nucleoside 1-TbAd, which is made abundantly by virulent but not avirulent Mycobacterium tuberculosis strains, and demonstrate that 1-TbAd regulates the pH and function of host macrophage endolysosomes.
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