Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3

July 8th, 2019 by Jark Böttcher

Nature Chemical Biology, Published online: 08 July 2019; doi:10.1038/s41589-019-0310-x

A chemical probe BI-9321 for the PWWP1 domain of NSD3 and its inactive analog were identified. BI-9321 binds to the methyl-lysine binding site, reduces the association of NSD3 with chromatin and inhibits proliferation of acute myeloid leukemia cells.
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