Visualizing a protonated RNA state that modulates microRNA-21 maturation

October 26th, 2020 by Jared T. Baisden

Nature Chemical Biology, Published online: 26 October 2020; doi:10.1038/s41589-020-00667-5

The authors identified a pH-dependent protonated status in the miR-21 precursor, which leads to additional base pairing in its secondary structure, thus affecting Dicer processing and miR-21 maturation.
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