Visualizing a protonated RNA state that modulates microRNA-21 maturation
October 26th, 2020 by Jared T. Baisden
Nature Chemical Biology, Published online: 26 October 2020; doi:10.1038/s41589-020-00667-5
The authors identified a pH-dependent protonated status in the miR-21 precursor, which leads to additional base pairing in its secondary structure, thus affecting Dicer processing and miR-21 maturation.