Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases

January 26th, 2015 by Jannik Bruun Larsen

Nature Chemical Biology 11, 192 (2015). doi:10.1038/nchembio.1733

Authors: Jannik Bruun Larsen, Martin Borch Jensen, Vikram K Bhatia, Søren L Pedersen, Thomas Bjørnholm, Lars Iversen, Mark Uline, Igal Szleifer, Knud J Jensen, Nikos S Hatzakis & Dimitrios Stamou

Trafficking and sorting of membrane-anchored Ras GTPases are regulated by partitioning between distinct membrane domains. Here, in vitro experiments and microscopic molecular theory reveal membrane curvature as a new modulator of N-Ras lipid anchor and palmitoyl chain partitioning. Membrane curvature was essential for enrichment in raft-like liquid-ordered phases; enrichment was driven by relief of lateral pressure upon anchor insertion and most likely affects the localization of lipidated proteins in general.

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