Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes

November 16th, 2020 by James Schiemer

Nature Chemical Biology, Published online: 16 November 2020; doi:10.1038/s41589-020-00686-2

The authors report PROTAC ternary complex structures involving the E3 ligase cIAP1 and target protein BTK, showing that cooperativity is not always correlated with degradation efficiency.
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