The splice is right

October 15th, 2018 by James Palacino

The splice is right

The splice is right, Published online: 15 October 2018; doi:10.1038/s41589-018-0147-8

Current drug discovery efforts focus on proteins because of their ability to form stable, structured pockets. A recent study demonstrates that targeting stable, structured bioactive RNA motifs, such as autocatalytic introns, may provide a novel method of expanding druggability and selectivity.

Corrigendum: SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

March 18th, 2016 by James Palacino

Nature Chemical Biology 12, 304 (2016). doi:10.1038/nchembio0416-304c

Author: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann,, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice

August 18th, 2015 by James Palacino

Nature Chemical Biology 11, 741 (2015). doi:10.1038/nchembio0915-741a

Author: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

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SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

June 1st, 2015 by James Palacino

Nature Chemical Biology 11, 511 (2015). doi:10.1038/nchembio.1837

Authors: James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Xiaolu Zhang, Mailin Van Hoosear, Youngah Shin, Donovan N Chin, Caroline Gubser Keller, Martin Beibel, Nicole A Renaud, Thomas M Smith, Michael Salcius, Xiaoying Shi, Marc Hild, Rebecca Servais, Monish Jain, Lin Deng, Caroline Bullock, Michael McLellan, Sven Schuierer, Leo Murphy, Marcel J J Blommers, Cecile Blaustein, Frada Berenshteyn, Arnaud Lacoste, Jason R Thomas, Guglielmo Roma, Gregory A Michaud, Brian S Tseng, Jeffery A Porter, Vic E Myer, John A Tallarico, Lawrence G Hamann, Daniel Curtis, Mark C Fishman, William F Dietrich, Natalie A Dales & Rajeev Sivasankaran

  • Posted in Nat Chem Biol, Publications
  • Comments Off on SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice