Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

April 6th, 2014 by Indran Mathavan

Nature Chemical Biology 10, 340 (2014). doi:10.1038/nchembio.1499

Authors: Indran Mathavan, Séverine Zirah, Shahid Mehmood, Hassanul G Choudhury, Christophe Goulard, Yanyan Li, Carol V Robinson, Sylvie Rebuffat & Konstantinos Beis

The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum of lasso peptides and opens the path to the development of new antibacterials.

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