Tetracenomycin X inhibits translation by binding within the ribosomal exit tunnel

June 29th, 2020 by Ilya A. Osterman

Nature Chemical Biology, Published online: 29 June 2020; doi:10.1038/s41589-020-0578-x

Structural and biochemical analysis reveal that tetracenomycin X acts as an inhibitor of protein synthesis by binding within the exit tunnel in a large ribosomal unit to prevent the prolongation of the nascent polypeptide chain.
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