<i>N</i><sup>6-</sup>Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

December 10th, 2018 by Honghui Ma

N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation

<i>N</i><sup>6-</sup>Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation, Published online: 10 December 2018; doi:10.1038/s41589-018-0184-3

ZCCHC4 was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m6A 4220 in 28S rRNA. 28S rRNA methylation affects global translation and cell growth and contributes to tumorigenesis in cancer cells.
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